Cells (Form and function)
- Membranes and transport
- Lipid bilayer
- Amphipathic phospholipids
- Hydrophobic core is a barrier
- O₂, CO₂ by simple diffusion
- Osmosis
- Water to higher solute concentration
- Aquaporins speed it up
- Transport proteins
- Channels: facilitated diffusion
- Pumps: ATP, against gradient
- Selective permeability
- Fluid mosaic model
- Integral and peripheral proteins
- Glycoproteins and glycolipids outside
- Recognition and adhesion
- Lipid bilayer
- Organelles
- Organelles
- Discrete subunits, specific functions
- Not wall, cytoskeleton, cytoplasm
- Cell fractionation
- Ultracentrifuge
- Nuclei pellet first
- Compartmentalization
- Nucleus: modify mRNA first
- Concentrate enzymes and substrates
- Lysosomes, phagocytic vacuoles
- Organelles
- Cell specialization
- Differentiation
- Zygote → unspecialized cells
- Gradients control gene expression
- Stem cells
- Divide endlessly, differentiate
- Niches: bone marrow, hair follicles
- Toti-, pluri-, multipotent
- Cell size and SA:V
- Gametes, blood cells, neurons, muscle
- Cube SA:V = 6 ÷ L
- Exchange: area; need: volume
- Differentiation